Gordon Research Conference 

Hormone-Dependent Cancers: Molecular mechanisms to tailored therapeutics

August 16-21, 2015

 

 

Registration, click here. Deadline July 19, 2015, but please apply early to ensure your attendance. 

For GRS program preceding this GRC, click here.

 

Program updated June 12, 2015

Confirmed speakers per session, click names for speaker bios (where available). In addition, short talks will be selected from the abstracts.

Afternoons are free for activities, and poster sessions will be held from 4-6pm.

 

 

 

SATURDAY, August 16

 

2:00 pm - 9:00 pm:          Arrival and Check-In

 

6:00 pm:                         Dinner

 

7:30 pm - 7:40 pm:          Welcome / Introductory Comments by GRC Site Staff

 

 

7:40 pm - 9:30 pm:       Keynote session: Emergent Themes in Cancer Research

Discussion Leaders:          Jason Carroll (Cancer Research UK, Universtity of Cambridge, United Kingdom), Wayne Tilley (University of Adelaide / Hanson                                               Institute, Australia)

 

7:40 pm - 8:10 pm:          William Hahn (Harvard Medical School, USA)

                                      "Systematic Approaches to Identify and Credential Cancer Targets"

8:10 pm - 8:25 pm:          Discussion

 

8:25 pm - 9:05 pm:          Peter Jones (Van Andel Research Institute, USA)

                                      "The Cancer Epigenome"

9:05 pm - 9:15 pm:          Discussion

 

9:15 pm - 9:30 pm:          Selected from Poster Abstracts - TBA

 

 

 

MONDAY, August 17

 

7:30 am - 8:30 am:          Breakfast

 

 

9:00 am - 12:30 pm:     Functional Genomics and Epigenomics: Informing Biology and Defining Novel Targets

Discussion Leaders:          Steffi Oesterreich (University of Pittsburgh, USA), Theresa Hickey (University of Adelaide, Australia)

 

9:00 am - 9:20 am:          Scott Tomlins (University of Michigan Medical School, USA)

                                      "Translating the Prostate Cancer Genome to Therapeutic Strategies"

9:20 am - 9:30 am:          Discussion

 

9:30 am - 9:50 am:          Sohrab Shah (University of British Columbia, Canada)

                                      "Cancer Genomes, Mutations and Tumor Evolution"

9:50 am - 10:00 am:        Discussion

 

10:00 am - 10:30 am:       Coffee Break

 

10:30 am - 10:50 am:       Xiaole Shirley Liu (Harvard School of Public Health, USA)

                                      "Using Genome-Wide CRISPR/Cas9 Knockout Screens to Identify Mechanisms Underlying Endocrine Resistance in Breast and                                                 Prostate Cancers"

10:50 am - 11:00 am:       Discussion

 

11:00 am - 11:10 am:       Selected from Poster Abstracts: Luca Magnani (Imperial College London, United Kingdom)

                                      "Genetic and Epigenetic Mechanisms of Resistance to Individual Endocrine Therapies"

11:10 am - 11:20 am:      Discussion

 

11:20 am - 11:30 am:       Selected from Poster Abstracts: Wilbert Zwart (Netherlands Cancer Institute, The Netherlands)

                                      "Genomics of Male Breast Cancer"

11:30 am - 11:40 am:      Discussion

 

11:40 am - 11:50 am:      Selected from Poster Abstracs: Mathieu Lupien (Princess Margaret Cancer Centre, Canada)

                                      "Epigenetics and Chromatin Regulation in Cancer"

11:50 am - 12:00 pm:      Discussion

 

12:00 pm - 12:10 pm:      Selected from Poster Abstracs: Ryan Bourgo (University of Chicago, USA)

                                      "Capture of Associated Targets on Chromatin (CATCH) Identifies the Presence of eRNAs at Transcriptional Enhancers"

12:10 pm - 12:15 pm:      Discussion

 

12:15 pm - 12:25 pm:      Selected from Poster Abstracs: Courtney Andersen (University of Pittsburgh, USA)

                                      "Identifying Predictive Biomarkers of Endocrine Responses in High-grade Serious Ovarian Cancer"

12:25 pm - 12:30 pm:      Discussion

 

12:30 pm:                       Lunch

 

1:30 pm - 4:00 pm:          Free time

 

4:00 pm - 6:00 pm:       Poster Session

 

6:00 pm:                         Dinner

 

 

7:30 pm - 9:30 pm:       Signaling Cross Talk: Driving Disease Progression and Treatment Resistance

Discussion Leaders:          Frank Claessens (KU Leuven, Belgium), Charlotte Bevan (Imperial College London, United Kingdom)

 

7:30 pm - 7:50 pm:          Patricia Elizalde (University of Buonos Aires, Argentina)

                                      "ErbB-2 Nuclear Function Drives Breast Cancer Growth, Metastasis, and Resistance to Therapy"

7:50 pm - 8:00 pm:          Discussion

 

8:00 pm - 8:20 pm:          Lori Friedman (Genentech Inc., USA)

                                      "Characterizing and Targeting Mutant PI3K in Cancer"

8:20 pm - 8:30 pm:          Discussion

 

8:30 pm - 8:40 pm:          Selected from Poster Abstracs: Hari Singhal (University of Chicago, USA)

                                      "Progesterone Receptor is a Non-Competitive Agonist of Estrogen Receptor and is Essential for Breast Cancer Prognosis"

8:40 pm - 8:50 pm:          Discussion

 

8:50 pm - 9:00 pm:          Selected from Poster Abstracs: Theresa Hickey (University of Adelaide, USA)

                                      "Androgen Receptor Action in ER-positive Breast Cancer"

9:00 pm - 9:10 pm:          Discussion

 

9:10 pm - 9:20 pm:          Selected from Poster Abstracs: Alicia Blessing (University of Houston, USA)

                                      "Identification of a Novel Coregulator, SH3YL1, that Interacts with the Androgen Receptor N-terminus"

9:20 pm - 9:30 pm:          Discussion

 

 

 

TUESDAY, August 18

 

7:30 am - 8:30 am:          Breakfast

 

9:00 am - 12:30 pm:     Novel Targets and Agents: Advancement to the Clinic

Discussion Leaders:          Felix Feng (University of Michigan, USA), Carol Lange (University of Minnesota, USA)

 

9:00 am - 9:20 am:          Suzanne Conzen (The University of Chicago, USA)

                                      "GR Action in Hormone-Dependent Cancers"

9:20 am - 9:30 am:          Discussion

 

9:30 am - 9:50 am:          Naomi Laing (AstraZeneca, USA)

                                      "Targeting Endocrine Resistance in Hormone Receptor Positive Breast Cancer Through Novel Combination Strategies"

 

9:50 am - 10:00 am:        Discussion

 

10:00 am - 10:25 am:       Coffee Break

 

10:25 am - 10:45 am:       Donald McDonnell (Duke University School of Medicine, USA)

                                      "Mining the Complexities of Nuclear Receptor Signaling for Novel Therapeutic Targets in Cancer"

10:45 am - 10:55 am:       Discussion

 

10:55 am - 11:15 am:       Alex Swarbrick (Garvan Institute of Medical Research, Australia)

                                      "ID4 Controls Luminal Lineage Commitment in Normal and Malignant Mammary Epithelium"

11:15 am - 11:25 am:       Discussion

 

11:25 am - 11:35 am:       Selected from Poster Abstracts: Shudong Wang (University of South Australia, Australia)

                                      "CDK9 Inhibitors in Prostate Cancer"

11:35 am - 11:40 am:       Discussion

 

11:40 am - 11:50 am:       Selected from Poster Abstracts: Valerie Barton (University of Colorado Denver Anschutz Medical Campus, USA)

                                      "Androgen Receptor (AR) Supports a Tumor Initiating Population in AR+ Triple-negative Breast Cancer"

11:50 am - 11:55 am:       Discussion

 

11:55 am - 12:05 am:       Selected from Poster Abstracts: Damir Verešlija (Royal College of Surgeons in Ireland)

                                      "Whole Genome Transcriptome Analysis of Sequential Breast to Brain Metastasis Uncovers New Signalling Pathways and Druggable                                         Targets"

12:05 am - 12:10 am:       Discussion

 

12:10 am - 12:20 am:       Selected from Poster Abstracts: TBA

12:20 am - 12:30 am:       Discussion

 

12:30 pm:                       Lunch

 

1:30 pm - 4:00 pm:          Free time

 

4:00 pm - 6:00 pm:       Poster Session

 

6:00 pm:                         Dinner

 

 

7:30 pm - 9:30 pm:       Metastasis: Models and Mechanisms

Discussion Leaders:          Dan Frigo (University of Houston, USA), Suzanne Fuqua (Baylor College of Medicine)

 

7:30 pm - 7:50 pm:          Alana Welm (Oklahoma Medical Research Foundation, USA)

                                      "Patient-Derived Xenografts as Models for Breast Cancer Metastasis"

7:50 pm - 8:00 pm:          Discussion

 

8:00 pm - 8:20 pm:          Ingun Holen (The University of Sheffield, United Kingdom)

                                      "The Role of the Microenvironment in Regulating Early Stages of Bone Metastasis in Breast and Prostate Cancer"

8:20 pm - 8:30 pm:          Discussion

 

8:30 pm - 8:40 pm:          Selected from Poster Abstracs: Greg Goodall (Centre For Cancer Biology, Australia)

                                      "The RNA Binding Protein Quaking Regulates Formation of circRNAs During EMT"

8:40 pm - 8:50 pm:          Discussion

 

8:50 pm - 9:00 pm:          Selected from Poster Abstracs: Saraswati Sukumar (Johns Hopkins University, USA)

                                      "HOXB7 and its Contribution to Hormone Resistance"

9:00 pm - 9:10 pm:          Discussion

 

9:10 pm - 9:20 pm:          Selected from Poster Abstracs: TBA

9:20 pm - 9:30 pm:          Discussion

 

 

 

WEDNESDAY, August 19

 

7:30 am - 8:30 am:          Breakfast

 

8:30 am:                         Group Photo

 

9:00 am - 12:30 pm:     Tumor Heterogeneity and Evolution

Discussion Leaders:          Scott Cramer (University of Colorado, Anschutz Medical Campus, USA), Gail Prins (University of Illinois, Chicago, USA)

 

9:00 am - 9:20 am:          Kornelia Polyack (Dana-Farber Cancer Center, USA)

                                      "Breast Tumor Evolution"

9:20 am - 9:30 am:          Discussion

 

9:30 am - 9:50 am:          Senthil Muthuswamy (Princess Margaret Cancer Centre, Canada)

                                      "Cell Polarity Protein Scribble Regulates Trafficking of Prolactin Receptor and Prolactin Signaling During Mammary Gland                                                       Development"

9:50 am - 10:00 am:        Discussion

 

10:00 am - 10:30 am:       Coffee Break

 

10:30 am - 10:40 am:       Selected from Poster Abstracs: Rama Khokha (University of Toronto, Canada)

                                      "Progesterone and Progesterone Receptor in Cancer Evolution"

10:40 am - 10:50 am:       Discussion

 

10:50 am - 11:00 am:       Selected from Poster Abstracs:  David Gallego Ortega (Garva Institute of Medical Research, Australia)

                                      "ELF5 Opposes Estrogen Action and is a Lethal Factor in Luminal Breast Cancer"

11:00 am - 11:10 am:       Discussion

 

11:10 am - 11:20 am:       Selected from Poster Abstracts: Amina Zoubeidi (Vancouver Prostate Centre, Canada)

                                      "Interplay Between the Androgen Receptor and Cell Plasticity in Enzalutamide Resistant Prostate Cancer"

11:20 am - 11:30 am:       Discussion

 

11:30 am - 11:40 am:       Selected from Poster Abstracts: Stefan Prekovic (KU Leuven, Belgium)

                                      "RNA Sequencing of Fast Proliferating Enzalutamide-resistant LNCaP-derived Cell Line Reveals Up-regulation of EZH2 and                                                       Alternation in EZH2 Signaling"

11:40 am - 11:45 am:       Discussion

 

11:45 am - 11:55 am:       Selected from Poster Abstracts: TBA

11:55 am - 12:00 am:       Discussion

 

12:00 am - 12:10 am:       Selected from Poster Abstracts: TBA

12:10 am - 12:15 am:       Discussion

 

12:15 am - 12:25 am:       Selected from Poster Abstracts: TBA

12:25 am - 12:30 am:       Discussion

 

12:30 pm:                       Lunch

 

1:30 pm - 4:00 pm:          Free time

 

4:00 pm - 6:00 pm:       Poster Session

 

6:00 pm:                         Dinner

 

7:00 pm - 7:30 pm:       Business Meeting:

                                      ~     Nominations and election for the next Vice Chair

                                      ~     Fill in conference evaluation forms

                                      ~     Discuss future site and scheduling preferences

 

 

7:30 pm - 9:30 pm:       Patient Derived Models of Cancer Initiation and Treatment Resistance

Discussion Leaders:          Ganesh Raj (University of Texas Southwestern Medical Center, USA), Lisa Butler (University of Adelaide, Australia)

 

7:30 pm - 7:50 pm:          Renea Taylor (Monash University, Australia)

                                      "PDX Models of Prostate Cancer"

7:50 pm - 8:00 pm:          Discussion

 

8:00 pm - 8:20 pm:          Valerie Weaver (University of California, San Francisco, USA)

                                      "The Role of the Tumor Microenvironment"

8:20 pm - 8:30 pm:          Discussion

 

8:30 pm - 8:40 pm:          Selected from Poster Abstracs: Alejandra Bruna (University of Cambridge, United Kingdom)

                                      "An Integrated Pipeline for Pharmaco-genomic Studies in Patient Derived Tumour Cells"

8:40 pm - 8:50 pm:          Discussion

 

8:50 pm - 9:00 pm:          Selected from Poster Abstracs: Elgene Lim (Garvan Institute of Medical Research, Australia)

                                      "Modelling Resistance in PDX Models"

9:00 pm - 9:10 pm:          Discussion

 

9:10 pm - 9:20 pm:          Selected from Poster Abstracs: TBA

9:20 pm - 9:30 pm:          Discussion

 

 

 

THURSDAY, August 20

 

7:30 am - 8:30 am:          Breakfast

 

9:00 am - 12:30 pm:     Hormone Receptor Structure and Mutations in Endocrine Resistance

Discussion Leaders:          Geoffrey Greene (University of Chicago, USA), Jennifer Richer (University of Colorado, USA)

 

9:00 am - 9:20 am:          Matthew Ellis (Washington University in St. Louis, USA)

                                      "Genomic Characterization of Mutations and Rearrangements in Breast Cancer"

9:20 am - 9:30 am:          Discussion

 

9:30 am - 9:50 am:          Scott Dehm (University of Minnesota, USA)

                                      "Genomic Blueprints for Constitutive Androgen Receptor Function in Prostate Cancer"

9:50 am - 10:00 am:        Discussion

 

10:00 am - 10:30 am:       Coffee Break

 

10:30 am - 10:40 am:       Sarat Chandarlapaty (Memorial-Sloan-Kettering Cancer Center, USA)

                                      "Estrogen Receptor Mutations in Breast Cancer Progression"

10:50 am - 11:00 am:       Discussion

 

11:00 am - 11:10 am:       Paraic Kenny (Albert Einstein College of Medicine, USA)

                                      "Mutant GATA3 Drives Precocious Lobuloalveolar Mammary Development and Promotes the Growth of Estrogen Receptor Positive                                           Xenograft Tumors"

11:10 am - 11:20 am:       Discussion

 

11:20 am - 11:30 am:       Selected from Poster Abstracts: Brendon Ladd (AstraZeneca)

                                      "Effective Combination Therapies in Endocrine Resistant Breast Cancers Harboring an ER Mutation"

11:30 am - 11:40 am:       Discussion

 

11:40 am - 11:50 am:       Selected from Poster Abstracts: Luke Selth (University of Adelaide)

                                      "Elucidation of the Androgen Receptor Interactome Identifies GRHL2 as a Novel Co-regulator"

11:50 am - 12:00 am:       Discussion

 

12:00 am - 12:10 am:       Selected from Poster Abstracts: TBA

12:10 am - 12:15 am:       Discussion

 

12:15 am - 12:25 am:       Selected from Poster Abstracts: TBA

12:25 am - 12:30 am:       Discussion

 

12:30 pm:                       Lunch

 

1:30 pm - 4:00 pm:          Free time

 

4:00 pm - 5:30 pm:       Poster Session

 

 

5:30 pm - 7:30 pm:       Keynote session: Future of Cancer Research - Challenges and Solutions

Discussion Leaders:          Robert Clarke (Georgetown University Medical Center, USA), Gail Risbridger (Monash University, Australia)

 

7:30 pm - 7:50 pm:          Myles Brown (Dana-Farber Cancer Institute, USA)

                                      "Is Omics the Answer?"

6:00 pm - 6:10 pm:          Discussion

 

6:10 pm - 6:30 pm:          Chris Sweeney (Dana-Farber Cancer Institute, USA)

                                      "Precision Medicine in a Heterogeneous World"

6:30 pm - 6:40 pm:          Discussion

 

6:40 pm - 7:00 pm:          Carlo Palmieri (University of Liverpool, United Kingdom)

                                      "The Bench and Bed in 21st Century Breast Cancer Research"

7:00 pm - 7:10 pm:          Discussion

 

7:10 pm - 7:30 pm:          Panel Discussion

 

 

8:00 pm:                         Dinner

 

 

 

FRIDAY, August 21

 

7:30 am - 8:30 am:          Breakfast

 

9:00 am                          Departure